SKorean scientists say cancer-killing virus developed

Started by Father Demon, October 19, 2006, 03:40:17 PM

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rjs246

#30
October 20, 2006, 05:51:13 PM
Can we go back to talking about sledgehammer rape?
Is rjs gonna have to choke a bitch?

Let them eat bootstraps.

MadMarchHare

#31
October 20, 2006, 07:32:04 PM
Several problems with this.  Adenovirus is self-replicating.  Any cell it infects will make thousands of copies of the virus, and explode, releasing the virus to infect neighboring cells.  Now, they said it only kills cancer cells.  Sounds like bullshtein to me.  Especially since they injected the virus directly into the tumor.  If it only kills tumor cells, give it systemically and it should still work.  So why didn't they - the simple answer is they did and it didn't work.  Probably because large particles are selectively cleared from the blood stream by the liver.  Remember the Geisinger kid at Penn? 

Nevermind the fact that several South Korean scientists have been nailed for modifying or outright falsifying data in the last few years.
Anyone but Reid.

Geowhizzer

#32
October 20, 2006, 07:45:09 PM
Party pooper.  ;)

Father Demon

#33
October 20, 2006, 07:50:40 PM
Sounds like someone is trying to protect his job.
The drawback to marital longevity is your wife always knows when you're really interested in her and when you're just trying to bury it.

MadMarchHare

#34
October 20, 2006, 07:51:55 PM
OK, I've read the article now, and all I gots to say is:   HAHAHAHAHAHAHAHAHA!

First off, the adenovirus is specific to human cells, and won't affect the mouse at all.  There is no way to evaluate tox AT ALL.  Second, direct injections into tumors is generally regarded as bullshtein.  The likelyhood that their virus will have no effect in a human patient is ridiculously low.  That it will target only the tumor cells is ludicrous.

No one does a Kaplan-Meier analysis of a xenograft.  No one.  You measure the size of the tumor with calipers, it's pretty easy.  Kaplan-Meier is really difficult to interpret, which is undoubtedly why it was used.

Finally, JNCI is where you publish when 4th and 5th tier journals say no.  There data seems OK, but there methods are terribly flawed, and this will almost certainly lead no where with respect to human impact.

For those that are interested, here's the article:  http://jncicancerspectrum.oxfordjournals.org/cgi/reprint/jnci;98/20/1482.pdf

Oh, and BTW, eat me Demon. ;)
Anyone but Reid.

Feva

#35
October 20, 2006, 08:02:58 PM
Nerd.
"Now I'm completing up the other half of that triangle" - Emmitt Smith on joining Troy Aikman and Michael Irvin in the Hall of Fame

"If you have sex with a prostitute against her will, is that considered rape or shoplifting?" -- 2 Live Stews

MadMarchHare

#36
October 20, 2006, 08:06:40 PM
Well, DUH!
Anyone but Reid.

Geowhizzer

#37
October 20, 2006, 10:43:50 PM
So, to boil it down for those of us that don't speak pharmaceuticals:  it won't work, huh?

MadMarchHare

#38
October 20, 2006, 11:25:06 PM
Well, they tried gene therapy in that Geisinger kid.  He went into multi-organ failure and died a week later.  My guess (and this isn't my expertise, mind you), you'd have a similar response with this.
Anyone but Reid.

Sgt PSN

#39
October 21, 2006, 03:09:31 AM
Now I'm feeling quite suckered in regards to my annual financial contributions to cancer research.  Find a cure bitches.  I only got about 25 more years of smoking left before I catch the cancer. 
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